Cu(II) homogeneous and heterogeneous catalysts for the asymmetric Henry reaction

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• 作者：Matthew D. Jones ; Christine J. Cooper ; Mary F. Mahon ; Paul. R. Raithby ; David Apperley ; Joanna Wolowska ; David Collison
• 关键词：Homogeneous and heterogeneous catalysts ; Copper ; Supported catalysts
• 刊名：Journal of Molecular Catalysis A: Chemical
• 出版年：2010
• 出版时间：15 June 2010
• 年：2010
• 卷：325
• 期：1-2
• 页码：8-14
• 全文大小：445 K

文摘

New Cu(II) complexes have been prepared and characterised via single crystal X-ray diffraction studies, EPR spectroscopy, elemental analysis and high resolution mass spectrometry. In all cases 1:2 (copper to ligand) stoichiometric complexes were isolated. The homogeneous Cu(II) complexes were tested for the asymmetric Henry reaction. Conversions in excess of 70 % were obtained with enantioselectivities in the range 0–78 % . Heterogeneous Cu(II) catalysts have been prepared. In these cases high conversions were obtained. However, after prolonged reaction time the main product observed was 1,3-dinitro-2-phenyl propane. The formation of this product can be curtailed by both decreasing the catalyst loading and employing shorter reaction times.