Maternal separation exacerbates Alzheimer’s disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice

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• 作者：Jianjun Hui^a ; ^c ; Gaifeng Feng^a ; ^b ; ^{gaifeng.feng@mail.xjtu.edu.cn} ; Caifeng Zheng^a ; ^c ; Hui Jin^a ; ^b ; Ning Jia^a ; ^b
• 关键词：Alzheimer&rsquo ; s disease (AD) ; Maternal separation(MS) ; Senile plaque ; Cholinergic neuron
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：318
• 期：Complete
• 页码：18-23
• 全文大小：1922 K
• 卷排序：318

文摘

Maternal separation exacerbates adult APPswe/PS1dE9 mice learning and memory deficits. Maternal separation increases senile plaques deposition in cortex and hippocampus in APPswe/PS1dE9 mice. Maternal separation decreases cholinergic neurons in nucleus basalis of Meynert in APPswe/PS1dE9 mice.