A novel electrochemical aptasensor based on Y-shape structure of dual-aptamer-complementary strand conjugate for ultrasensitive detection of myoglobin
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- 作者：Seyed Mohammad Taghdisia ; Noor Mohammad Daneshb ; c ; Mohammad Ramezanib ; Ahmad Sarreshtehdar Emranid ; abnouskh@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Khalil Abnouse ; ahmad_sarreshtedar@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Electrochemical aptasensor ; Y-shape structure ; Exonuclease I ; Myoglobin
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：532-537
- 全文大小：1093 K
文摘
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Myoglobin (Mb) is one of the best indicators of Acute myocardial infarction (AMI).
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Here, a novel electrochemical aptasensor was developed for ultrasensitive and selective detection of Mb.
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The fabricated aptasensor showed high selectivity toward Mb with a limit of detection (LOD) as low as 27 pM.
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Besides, the developed aptasensor was effectively applied to detect Mb in human serum.