- 作者：Sven Jarius ; Jette Frederikson ; Patrick Waters ; Friedemann Paul ; Gulsen Akman-Demir ; Romain Marignier ; Diego Franciotta ; Klemens Ruprecht ; Bettina Kuenz ; Paulus Rommer ; Wolfgang Kristoferitsch ; Brigit
- 关键词：Neuromyelitis optica (NMO) ; Devic disease ; Devic's disease ; Optic neuritis ; Longitudinally extensive transverse myelitis ; NMO-IgG ; Antibodies to aquaporin-4 ; Multiple sclerosis
- 刊名：Journal of the Neurological Sciences
- 出版年：2010
- 出版时间：15 November 2010
- 年：2010
- 卷：298
- 期：1-2
- 页码：158-162
- 全文大小：213 K
To assess the frequency of AQP4-Ab in patients with optic neuritis (ON), and to investigate the prognostic implications of AQP4-Ab seropositivity in such patients. AQP4-Ab serum levels were determined in 224 individuals from Austria, Denmark, France, Germany, Italy, and Turkey using a newly developed fluorescence immunoprecipitation assay employing recombinant human AQP4. AQP4-Ab were detectable in 8/139 (5.8 % ) patients with acute monosymptomatic optic neuritis (AMON) and in 10/17 (58.8 % ) patients with established NMO and a last relapse of acute ON (NMO/ON), but not in 32 patients with multiple sclerosis or in 36 healthy controls. At last examination, 4/8 (50 % ) seropositive AMON patients had met the criteria for NMO but 0/128 seronegative AMON patients. Disease severity differed significantly between seropositive and seronegative AMON. Complete bilateral or unilateral blindness occurred in six AQP4-Ab positive patients, but only in one AQP4-Ab negative patient. AQP4-Ab levels did not vary between seropositive AMON and NMO/ON and did not correlate with disease severity. Female gender, a relapsing course, and concomitant autoimmunity were associated with AQP4-Ab seropositive status and risk of developing NMO. AQP4-Ab is relatively rare among patients with AMON, but if present it predicts a high rate of conversion to NMO within one year.