Spatial distributions of phosphorylated membrane proteins aquaporin 0 and MP20 across young and aged human lenses
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- 作者：Danielle B. Gutierreza ; 1 ; Donita L. Garlandb ; 2 ; John H. Schwackec ; 3 ; David L. Hacheyd ; Kevin L. Scheyd ; k.schey@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aquaporin 0 ; Phosphorylation ; Mass spectrometry ; Membrane protein ; MP20 ; Ocular lens
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：149
- 期：Complete
- 页码：59-65
- 全文大小：967 K
文摘
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10">Distributions of pAQP0 and pMP20 change with age and across human lens regions.
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15">MP20 pSer170 peaks in the cortex and decreases with lens age in the nucleus.
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AQP0 pSer235 peaks in the inner cortex and declines with lens age in the nucleus.
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A decrease in AQP0 pSer235 in aged lenses correlates with the permeability barrier.
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AQP0 pSer229 is minor, but levels remain steady into the nucleus and with lens age.