Effects of L-dopa priming on cortical high beta and high gamma oscillatory activity in a rodent model of Parkinson's disease
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- 作者：Kristin B. Dupre ; Ana V. Cruz ; Alex J. McCoy ; Claire Delaville ; Colin M. Gerber ; Katherine W. Eyring ; Judith R. Walters ; waltersj@ninds.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; serotonin ; 6-OHDA ; 6-hydroxydopamine ; 8-OH-DPAT ; (+)-8-hydroxy-2-(dipropylamino)tetralin hydrobromide ; AIMs ; abnormal involuntary movements ; ALO ; axial ; limb ; and orolingual ; benserazide ; dl-serine 2-(2 ; 3 ; 4-trihydroxybenzyl) hydrazide hydrochloride ; Aq ; aqueduct (Sylvius) ; DA ; dopamine ; DPAT ; 8-OH-DPAT ; FFT ; fast Fourier-transform ; FTG ; finely-tuned gamma ; GPi ; globus pallidus internal segment ; i.p. ; intraperitoneally ; L-dopa ; levodopa ; LFP ; local field potential ; PCA ; principal component
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：1-15
- 全文大小：2262 K
文摘
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L-dopa reduces cortical high beta LFP activity while inducing dyskinesia.
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L-dopa elicits the co-emergence of cortical high gamma LFP activity and dyskinesia.
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D1 and D2 agonists individually induce cortical high gamma and dyskinesia.
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5-HT1A agonist reduces dyskinesia and cortical high gamma but increases high beta.
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Phase-locking of cortical spikes is negatively correlated with high gamma LFP.