Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy
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- 作者：Marco Fuenzalidaa ; marco.fuenzalida@uv.cl" class="auth_mail" title="E-mail the corresponding author ; Claudia Espinozaa ; Miguel Á ; ngel Pé ; reza ; Cheril Tapia-Rojasb ; Loreto Cuitinob ; Enrique Brandanb ; Nibaldo C. Inestrosab ; c ; d ; ninestrosa@bio.puc.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACSF ; artificial cerebrospinal fluid ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ; ANDRO ; andrographolide ; APV ; 2-amino-5-phosphonovaleric acid ; AraC ; 1-β-D-arabinofuranosylcytosine ; CaMKII ; calmodulin-dependent protein kinase II ; CNQX ; 6-cyano-7-nitroquinoxaline-2 ; 3-dione ; DGC ; dystrophin-associated glycoprotein complex ; DMD ; Duchenne muscular dystrophy ; EPSC ; excitatory postsynaptic currents ; fIPSP ; field inhibitory postsynaptic potentials ; fEPSP ; field excitatory posts
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：109-120
- 全文大小：1817 K
文摘
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The functional GABAergic synaptic connection is reduced in mdx mice.
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Activation of Wnt signaling increases the clustering of GABAA receptors.
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Wnt-5a and Andrographolide, improve hippocampal mdx GABAergic efficacy.
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Wnt signaling could be a promising novel target for DMD cognitive therapy.