Recombinant human soluble thrombomodulin safely and effectively rescues acute promyelocytic leukemia patients from disseminated intravascular coagulation

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• 作者：Takayuki Ikezoe ; Asako Takeuchi ; Mayuka Isaka ; Yu Arakawa ; Naomi Iwabu ; Tsukie Kin ; Kazuki Anabuki ; Mizu Sakai ; Ayuko Taniguchi ; Kazuto Togitani ; Akihito Yokoyama
• 关键词：Acute promyelocytic leukemia ; Recombinant human soluble thrombomodulin ; All-trans retinoic acid ; Disseminated intravascular coagulation
• 刊名：Leukemia Research
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：36
• 期：11
• 页码：1398-1402
• 全文大小：318 K

文摘

We treated individuals for disseminated intravascular coagulation (DIC) caused by acute promyelocytic leukemia (APL) (n = 9) using human soluble thrombomodulin (rTM) in combination with all-trans retinoic acid (ATRA) and chemotherapy, and compared the clinical outcomes with historical control patients (n = 8) treated with ATRA and/or chemotherapy. Two control patients developed intracranial vascular incidents. On the other hand, no bleeding related mortality was noted in rTM-treated patients. Notably, treatment with rTM rescued patients from DIC earlier than historical controls (log rank test, p = 0.019). These results suggest that administration of rTM should be considered for the treatment of individuals with DIC associated with APL.