Noninvasive Identification of Ventricular Tachycardia-Related Conducting Channels Using Contrast-Enhanced Magnetic Resonance Imaging in Patients With Chronic Myocardial Infarction: Comparison of Signal Intensity Scar Mapping and Endocardial Voltage Mappin

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• 作者：Esther Perez-David MD ; Á ; ngel Arenal MD ; ^{arenal@secardiologia.es} ; Jos&#xe9 ; L. Rubio-Guivernau PhD^† ; ; Roberto del Castillo MD ; Leonardo Atea MD ; Elena Arbelo MD ; PhD^‡ ; ; Eduardo Caballero MD ; PhD^‡ ; ; Veró ; nica Celorrio MD ; Tomas Datino MD ; PhD ; Esteban Gonzalez-Torrecilla MD ; PhD ; Felipe Atienza MD ; Maria J. Ledesma-Carbayo PhD^† ; ; Javier Bermejo MD ; Alfonso Medina MD ; PhD^‡ ; ; Francisco Fern&#xe1 ; ndez-Avil&#xe9 ; s MD ; PhD
• 关键词：ablation ; heterogeneous imaging ; magnetic resonance imaging ; ventricular tachycardia
• 刊名：Journal of the American College of Cardiology
• 出版年：2011
• 出版时间：11 January 2011
• 年：2011
• 卷：57
• 期：2
• 页码：184-194
• 全文大小：3017 K

文摘

Objectives

We performed noninvasive identification of post-infarction sustained monomorphic ventricular tachycardia (SMVT)–related slow conduction channels (CC) by contrast-enhanced magnetic resonance imaging (ceMRI).

Background

Conduction channels identified by voltage mapping are the critical isthmuses of most SMVT. We hypothesized that CC are formed by heterogeneous tissue (HT) within the scar that can be detected by ceMRI.

Methods

We studied 18 consecutive VT patients (SMVT group) and 18 patients matched for age, sex, infarct location, and left ventricular ejection fraction (control group). We used ceMRI to quantify the infarct size and differentiate it into scar core and HT based on signal-intensity (SI) thresholds (>3 SD and 2 to 3 SD greater than remote normal myocardium, respectively). Consecutive left ventricle slices were analyzed to determine the presence of continuous corridors of HT (channels) in the scar. In the SMVT group, color-coded shells displaying ceMRI subendocardial SI were generated (3-dimensional SI mapping) and compared with endocardial voltage maps.

Results

No differences were observed between the 2 groups in myocardial, necrotic, or heterogeneous mass. The HT channels were more frequently observed in the SMVT group (88 % ) than in the control group (33 % , p < 0.001). In the SMVT group, voltage mapping identified 26 CC in 17 of 18 patients. All CC corresponded, in location and orientation, to a similar channel detected by 3-dimensional SI mapping; 15 CC were related to 15 VT critical isthmuses.

Conclusions

SMVT substrate can be identified by ceMRI scar heterogeneity analysis. This information could help identify patients at risk of VT and facilitate VT ablation.