- 作者：Aless ; ra Del Felice ; Chiara Arcaro ; Silvia Francesca Storti ; Antonio Fiaschi ; Paolo Manganotti
- 关键词：Electrical source imaging (ESI) ; High density EEG (256 channels) ; Epilepsy ; Sleep ; Spike generators ; Spindles generators
- 刊名：Clinical Neurophysiology
- 出版年：December, 2013
- 年：2013
- 卷：124
- 期：12
- 页码：2336-2344
- 全文大小：1794 K
Objective
To determine whether temporal epileptic patients and normal volunteers display similar sleep spindles鈥?cortical generators as determined by electrical source imaging (ESI), and whether such generators overlap in epilepsy patients with the epileptogenic zone identified by ESI.Methods
Twelve healthy subjects and twelve temporal lobe pharmaco-resistant epileptic patients underwent a 256-channel EEG recording during a daytime nap. Sleep spindles were analyzed off line, distinguishing slow (10-12 Hz) and fast (12-14 Hz) ones, and the final averaged signal was projected onto a MNI (Montreal Neurological Institute) space to localize cortical generators. The same procedure was performed for averaged epileptic spikes, obtaining their cortical source. Intra- and inter-group statistical analyses were conducted.
Results
Multiple, concomitant generators were detected in both populations for slow and fast spindles. Slow spindles in epileptics displayed higher source amplitude in comparison to healthy volunteers (Z = 0.001), as well as a preferential localization over the affected temporal cortices (p = 0.039). Interestingly, at least one of slow spindles鈥?generators overlapped with the epileptogenic zone.
Conclusion
Slow spindles, but not fast ones, in temporal epilepsy are mainly generated by the affected temporal lobe.
Significance
These results point to the strict relation between sleep and epilepsy and to the possible cognitive implications of spikes arising from memory-encoding brain structures.