Mise en place d'un indicateur d'exposition aux antibiotiques au centre hospitalier université de DijonImplementation of a monitoring system for the consumption of antibiotics in the Dijon univers

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• 作者：N. Marchiset-Ferlay ; C. Pernot ; M. P. Guenfoudi ; Albuisson ; N. Garnier ; A. Lazzarotti ; M. J. Durnet-Archeray ; P. Chavanet
• 关键词：Liver organ transplantation ; Listeria monocytogenes ; Sepsis ; Pleural effusion ; Antimicrobial resistanceAuthor Keywords ; Transplantation hé ; patique ; Listeria monocytogenes ; Sepsis ; Pleuré ; sie ; Ré ; sistance aux anti
• 刊名：Médecine et Maladies Infectieuses
• 出版年：2003
• 出版时间：1 February 2003
• 年：2003
• 卷：33
• 期：2
• 页码：84-92
• 全文大小：176 K

文摘

Introduction. – The increasing consumption of antibiotics in hospitals and the economic implications of this increase lead to assessing this consumption. The increased incidence of infections involving multi-resistant bacteria incited healthcare authorities to carryout a close observation of antibiotic practices in the various hospital units.

Method. – The authors chose to measure antibiotic consumption at the Dijon University Hospital with the Penetration Index which takes into account the quantity of antibiotics in grams (the Defined Daily Dose according to the WHO) and the number of patients-days in hospital (as an index of the activity of the various medical units). This standardized method allowed to add the penetration index of various antibiotic classes. The penetration index was calculated each trimester for each antibiotic and unit, between 1996 and 1999.

Results. – There was a significant increase in antibiotic consumption in the intensive care units, surgery units and pediatric intensive care unit (P < 0.05). The evaluation method was sufficiently sensitive to reveal specific variations in consumption, such as a drop in consumption of glycopeptides in 1998 or change in fluconazole use.

Comments. – The penetration index is a sensitive monitoring method allowing to track variations in antibiotic consumption while taking into account the level of activity in the various medical units.