Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation

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• 作者：Claudine M. Kraan ; Darren R. Hocking ; Nellie Georgiou-Karistianis ; Sylvia A. Metcalfe ; Alison D. Archibald ; Joanne Fielding ; Julian Trollor ; John L. Bradshaw ; Jonathan Cohen ; Kim M. Cornish
• 关键词：Fragile X Tremor Ataxia Syndrome (FXTAS) ; Fragile X Mental Retardation gene 1 (FMR1) ; Fragile X Mental Retardation protein (FMRP) ; Cerebellar motor networks ; Cognitive-neuromotor interaction ; Physiological Profile Assessment ; Postural control
• 刊名：Behavioural Brain Research
• 出版年：2013
• 出版时间：15 September, 2013
• 年：2013
• 卷：253
• 期：Complete
• 页码：329-336
• 全文大小：1376 K

文摘

Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures from the Physiological Profile Assessment (Lord et al., 2003 ) were conducted in 28 female PM-carriers (mean age: 41.32 ¡À 8.03) and 31 female controls with normal FMR1 alleles (mean age: 41.61 ¡À 8.3). Multiple regression analyses were conducted to examine the moderating role of CGG-repeat length on the relation between age and postural sway under dual-task interference. In female PM-carriers, our results showed significantly poorer proprioceptive awareness, slower reaction time, and greater postural displacement when performing a concurrent verbal fluency task. Significantly, these findings showed age- and genetically-modulated changes in dual-task postural displacement in the medio-lateral direction in female PM-carriers. These findings highlight the sensitivity of postural control paradigms in identifying early cerebellar postural changes that may act as surrogate markers of future decline in female PM-carriers.