When less is more: novel mechanisms of iron conservation

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• 作者：Marina Bayeva ; Hsiang-Chun Chang ; Rongxue Wu ; Hossein Ardehali
• 关键词：iron deficiency ; metabolism ; diabetes ; tristetraprolin ; Cth1/2
• 刊名：Trends in Endocrinology and Metabolism
• 出版年：November, 2013
• 年：2013
• 卷：24
• 期：11
• 页码：569-577
• 全文大小：507 K

文摘

Disorders of iron homeostasis are very common, yet the molecular mechanisms of iron regulation remain understudied. Over 20 years have passed since the first characterization of iron-regulatory proteins (IRP) as mediators of cellular iron-deficiency response in mammals through iron acquisition. However, little is known about other mechanisms necessary for adaptation to low-iron states. In this review, we present recent evidence that establishes the existence of a new iron-regulatory pathway aimed at iron conservation and optimization of iron use through suppression of nonessential iron-consuming processes. Moreover, we discuss the possible links between iron homeostasis and energy metabolism uncovered by studies of iron-deficiency response.