Correlation of the Corneal Collagen Cross-Linking Demarcation Line Using Confocal Microscopy and Anterior Segment Optical Coherence Tomography in Keratoconic Patients

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• 作者：George D. Kymionis ; Michael A. Grentzelos ; Argyro D. Plaka ; Konstantinos I. Tsoulnaras ; Vasilios F. Diakonis ; Dimitrios A. Liakopoulos ; Vardhaman P. Kankariya ; Aristophanis I. Pallikaris
• 刊名：American Journal of Ophthalmology
• 出版年：January, 2014
• 年：2014
• 卷：157
• 期：1
• 页码：110-115.e1
• 全文大小：630 K

文摘

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Purpose

To evaluate and compare the depth of the corneal stromal demarcation line after corneal collagen cross-linking (CXL) using 2 different methods: confocal microscopy and anterior segment optical coherence tomography (AS OCT).

Design

Prospective, comparative, interventional case series.

Methods

Seventeen patients (18 eyes) with progressive keratoconus were enrolled. All patients underwent uneventful CXL treatment according to the Dresden protocol. One month after surgery, corneal stromal demarcation line depth was measured in all patients by 2 independent observers using confocal microscopy and AS OCT.

Results

Mean corneal stromal demarcation line depth measured using confocal microscopy by the first observer was 306.22 卤 51.54聽渭m (range, 245 to 417聽渭m) and that measured by the second observer was 303.5 卤 46.98聽渭m (range, 240 to 390聽渭m). The same measurements using AS OCT were 300.67 卤 41.56聽渭m (range, 240 to 385聽渭m) and 295.72 卤 41.01聽渭m (range, 228 to 380聽渭m) for the first and second observer, respectively. Pairwise comparisons did not reveal any statistically significant difference between confocal microscopy and AS OCT measurements for both observers (P聽= .3219 for the first observer and P聽= .1731 for the second observer).

Conclusions

Both confocal microscopy and AS OCT have similar results in evaluating the depth of the corneal stromal demarcation line after CXL.