The endothelium as the common denominator in malignant hypertension and thrombotic microangiopathy
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- 作者：Roy O. Mathew ; MDa ; c ; 1 ; roy.mathew@va.gov" class="auth_mail" title="E-mail the corresponding author ; Ali Nayer ; MDb ; Arif Asif ; MDc
- 关键词：Malignant hypertension ; thrombotic microangiopathy ; endothelial dysfunction ; hemolytic uremic syndrome
- 刊名：Journal of the American Society of Hypertension
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：10
- 期：4
- 页码：352-359
- 全文大小：1477 K
文摘
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Endothelial dysfunction underlie thrombotic microangiopathies and malignant hypertension.
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Endothelial dysfunction likely promotes hypertension and microangiopathic hemolytic anemia.
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Alternative complement activation may also be important in malignant hypertension and TMA.
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Reducing endothelial injury via complement inhibition beneficial in atypical HUS.
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Clinical trials needed to test targeting endothelium in TTP and malignant hypertension.