Molecular Structures of Transcribing RNA Polymerase I

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• 作者：Lucas Tafur¹ ; Yashar Sadian¹ ; Niklas A. Hoffmann¹ ; Arjen J. Jakobi¹ ; ² ; Rene Wetzel¹ ; Wim J.H. Hagen¹ ; Carsten Sachse¹ ; Christoph W. Mü ; ller¹ ; ³ ; ^{cmueller@embl.de}
• 关键词：RNA polymerase I ; Pol I ; transcription ; elongation complex ; rDNA transcription ; cryoelectron microscopy
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：64
• 期：6
• 页码：1135-1143
• 全文大小：3470 K
• 卷排序：64

文摘

Pol I gradually closes its DNA-binding cleft during elongation complex formation Pol I bridge helix folds into a conformation similar to that in other RNA polymerases During elongation, the Pol I A12.2 C-terminal domain is excluded from the cleft A49 tandem winged helix domain contacts upstream DNA, similar to TFIIE