Efficient synthesis of trifluoromethylated dihydrochalcones, aryl vinyl ketones and indanones by superelectrophilic activation of 4,4,4-trifluoro/3-(trifluoromethyl)crotonic acids
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- 作者：G.K. Surya Prakash ; Farzaneh Paknia ; Arjun Narayanan ; Golam Rasul ; Thomas Mathew ; George A. Olah
- 关键词：Crotonic acid ; Friedel&ndash ; Crafts reaction ; Trifluoromethyl dihydrochalcones ; Trifluoromethylindanones ; Acylation/cyclialkylation ; Ab initio theory
- 刊名：Journal of Fluorine Chemistry
- 出版年：2012
- 出版时间：November, 2012
- 年：2012
- 卷：143
- 期：Complete
- 页码：292-302
- 全文大小：979 K
文摘
Superacid catalyzed electrophilic substitution of arenes using 4,4,4,-trifluoro/3-trifluoromethylcrotonic acids has been investigated. The direct synthesis of various trifluoromethylated dihydrochalcones, aryl vinyl ketones and indanones has been achieved by this methodology. It has been found that the position of the trifluoromethyl group has a profound effect on the nature of the reaction and the products. In the pharmaceutical industry, many fluoroorganics are shown to possess significant biological and therapeutic activities. Therefore, these novel compounds can be considered key intermediates for the preparation of potential biologically active molecules.