Synthesis of perimidine and 1,5-benzodiazepine derivatives using tamed Br?nsted acid, BF₃-H₂O

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• 作者：G.K. Surya Prakash ; Farzaneh Paknia ; Arjun Narayan ; Thomas Mathew ; George A. Olah
• 关键词：Brø ; nsted acid ; Diamines ; Benzodiazepines ; Perimidines ; Condensation-cyclization
• 刊名：Journal of Fluorine Chemistry
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：152
• 期：Complete
• 页码：99-105
• 全文大小：1971 K

文摘

The one pot synthesis of perimidine and 1,5-benzodiazepine derivatives via condensation of aryldiamines with ketones in the presence of BF₃-H₂O is described. BF₃-H₂O plays a dual role, as an efficient non-oxidizing Br?nsted acid catalyst as well as an effective solvent making the reaction more economic and environmentally safer. The reaction is simple, fast and convenient.