Fused Mycobacterium tuberculosis multi-stage immunogens with an Fc-delivery system as a promising approach for the development of a tuberculosis vaccine
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- 作者：Arman Mosavata ; b ; Saman Soleimanpoura ; b ; 1 ; Hadi Farsiania ; b ; 1 ; Hamid Sadeghianc ; Kiarash Ghazvinib ; Mojtaba Sankiand ; Saeid Amel Jamehdarb ; Seyed Abdolrahim Rezaeee ; RezaeeR@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：CFP-10 ; Fc-delivery system ; HspX ; Multi-stage immunogens ; Mycobacterium tuberculosis ; Subunit vaccine
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：163-172
- 全文大小：1359 K
文摘
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We cleared that Fc-delivery system could be induce appropriate Th1 immune response.
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Our novel fusion protein produced in high efficiently yeast expression system.
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We designed a new multi-stage fusion protein from M.tb as a subunit vaccine candidate.
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We studied molecular modeling of Fc-based fusion protein.
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We assessed the immunogenicity of Fc-based recombinant fusion protein in mice model.
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M.tb: Mycobacterium tuberculosis