A heterogeneous population of nuclear-encoded mitochondrial mRNAs is present in the axons of primary sympathetic neurons
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- 作者：Armaz Aschrafi ; Amar N. Kar ; Jenna R. Gale ; Abdel G. Elkahloun1 ; Jose Noberto S. Vargas ; Naomi Sales ; Gabriel Wilson ; Miranda Tompkins ; Anthony E. Gioio ; Barry B. Kaplan ; kaplanb@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microarray analyses ; mRNAs ; Subcellular localization ; Superior cervical ganglion ; Campenot cell culture chambers
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：18-23
- 全文大小：718 K
文摘
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The axonal mitochondrial mRNA population was annotated by microarray analysis.
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These data were validated by qPCR methodology and in situ hybridization.
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Axons contain > 100 different nuclear-encoded mitochondrial mRNAs.
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Mitochondrial mRNAs are highly enriched in the axons of sympathetic neurons.
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Proteins encoded by these mRNAs function in several diverse biological processes.