Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part I: Fathead minnow
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- 作者：Krysta R. Nelsona ; Anthony L. Schroederb ; c ; aschroed@crk.umn.edu" class="auth_mail" title="E-mail the corresponding author ; Gerald T. Ankleyb ; Brett R. Blackwelld ; Chad Blanksmae ; Sigmund J. Degitzb ; Kevin M. Flynnb ; Kathleen M. Jensenb ; Rodney D. Johnsonb ; Michael D. Kahlb ; Dries Knapenf ; Patricia A. Kosianb ; Rebecca Y. Milskd ; Eric C. Randolpha ; Travis Saaria ; Evelyn Stinckensf ; Lucia Vergauwenf ; Daniel L. Villeneuveb
- 关键词：ANOVA ; analysis of variance ; AOP ; adverse outcome pathway ; CVs ; coefficents of variance ; dpf ; days post fertilization ; FELS ; fish early life stage ; hpf ; hours post-fertilization ; HPLC ; high performance liquid chromatography ; LC-MS/MS ; liquid chromatography-tandem mass spectrometry ; LSW ; lake superior water ; MS-222 ; tricaine methanesulfonate ; MBT ; 2-mercaptobenzothiazole ; RSCABS ; Rao&ndash ; Scott adjusted Cochran&ndash ; Armitage test for trend by slices ; T3 ; triiodothyronine ; T4 ; thyroxine ; TPO ; th
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：173
- 期：Complete
- 页码：192-203
- 全文大小：1145 K
文摘
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Fathead minnows were exposed to a known thyroid peroxidase (TPO) inhibitor, MBT.
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Reductions in whole body thyroid hormone (T3, T4) were observed.
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Follicular cell hyperplasia and increased TPO mRNA suggested compensation.
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Anterior, but not posterior, swim bladder inflation was delayed and/or impaired.
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Non-thyroid mediated actions of MTB on swim bladder inflation cannot be ruled out.