Surveillance in cholangiocellular carcinoma

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• 作者：Dr. Thomas C. Wirth ; MD/PhD (Fellow) ; Prof. Dr. Arndt Vogel ; MD/PhD ; ^{Vogel.Arndt@mh-hannover.de} (Senior Consultant)
• 关键词：Cholangiocellular carcinoma ; Surveillance ; Primary sclerosing cholangitis
• 刊名：Best Practice & Research Clinical Gastroenterology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：30
• 期：6
• 页码：987-999
• 全文大小：782 K
• 卷排序：30

文摘

Cholangiocellular carcinoma is the most frequent malignant neoplasm originating from the epithelium of intra- or extrahepatic bile ducts. In the past decades, the incidence of cholangiocarcinoma has been shown to increase while overall mortality has remained high with an approximate 5-year overall survival below 20%. Surgery remains the only curative option while systemic treatment is limited to palliative chemotherapy. Therefore, surveillance strategies for patients at risk of developing cholangiocarcinoma are urgently needed, particularly in patients with primary sclerosing cholangitis and patients infected with liver flukes. Here we summarize the currently available data on surveillance of risk populations and methods for the detection of cholangiocarcinoma.