Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites
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- 作者：Kelly A. Teske ; Jonathon W. Bogart ; Luis M. Sanchez ; Olivia B. Yu ; Joshua V. Preston ; James M. Cook ; Nicholas R. Silvaggi ; Daniel D. Bikle ; Leggy A. Arnold ; arnold2@uwm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vitamin D receptor ; 1 ; 25(OH)2D3 ; Metabolites ; Lithocholic acid ; Calcitroic acid ; CYP24A1 ; DU145
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：238-246
- 全文大小：674 K
文摘
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Calcitroic acid acts as a vitamin D receptor agonist.
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Lithocholic acid glucuronides activate vitamin D receptor-mediated transcription.
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CYP24A1 is regulated by calcitroic acid and lithocholic acid glucuronides in prostate cancer cells.