Is the Molecular Clock Ticking Differently in Bipolar Disorder?

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• 作者：S. Bengesser^a ; N. Lackner^a ; A. Birner^a ; B. Reininghaus^a ; U. Heilbronner^a ; R. Fuchs^b ; N. Allard^b ; S. Wallner-Liebmann^b ; A. Rieger^a ; R. Queissner^a ; K. Filic^a ; F. Fellendorf^a ; E. Petek^c ; C. Windpassinger^c ; C. Schö ; rkhuber^a ; C. Gigler^a ; K. Gatkowsky^a ; T. Macheiner^a ; N. Kainzbauer^a ; E. Reininghaus^a
• 刊名：European Psychiatry
• 出版年：2015
• 出版时间：28-31 March 2015
• 年：2015
• 卷：30
• 期：supp_S1
• 页码：557
• 全文大小：52 K

文摘

Bipolar Disorder is a devastating disease with a genetic heritability. An orchestra of around 500 gene variants is leading to vulnerability.

One interesting candidate gene group are the socalled CLOCK GENES. The molecular 24h clock has several CLOCK GENES and the last gene ARNTL encodes for an activator of MAOA transcription and leads therefore to changes in neurotransmitter levels.

Methods

Genotyping of 150 paricipants with Bipolar Disorder and 78 healthy controls with the Illumina GWAS chip Omniexpress 1.1. Hypothesis driven extraction of ARNTL SNPs with the software PLINK. Statistical analysis with Chi square test with SPSS.

Results

Patients with Bipolar Disorder differ significantly in ARNTL genotypes compared to healthy controls. Details are presented during the poster session.

Discussion

Circadian rhythms seem to play an important pathogenetic mechanism in Bipolar Disorder.