Chemical kinetics for drug discovery to combat protein aggregation diseases

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• 作者：Paolo Arosio ; Michele Vendruscolo ; Christopher M. Dobson ; Tuomas P.J. Knowles ^{tpjk2@cam.ac.uk" class="auth_mail}
• 关键词：inhibition mechanism ; neurodegenerative diseases ; therapeutics ; aggregation kinetics
• 刊名：Trends in Pharmacological Sciences
• 出版年：March, 2014
• 年：2014
• 卷：35
• 期：3
• 页码：127-135
• 全文大小：855 K

文摘

Protein misfolding diseases are becoming increasingly prevalent, yet there are very few effective pharmacological treatments. The onset and progression of these diseases is associated with the aberrant aggregation of normally soluble proteins and peptides into amyloid fibrils. Because genetic and physiological findings suggest that protein aggregation is a key event in pathogenesis, an attractive therapeutic strategy against this class of disorders is the search for compounds able to interfere with this process, in particular by suppressing the formation of soluble toxic oligomeric aggregates. In this review, we discuss how chemical kinetics can contribute to the fundamental understanding of the molecular mechanism of aggregation, and speculate on the implications for the development of therapeutic molecules that inhibit specific steps in the aggregation pathway that are crucial for preventing toxicity.