Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge
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- 作者：Simon Brayford1 ; Nicole S. Bryce1 ; Galina Schevzov1 ; Elizabeth M. Haynes2 ; James E. Bear2 ; Edna C. Hardeman3 ; Peter W. Gunning1 ; p.gunning@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Biology
- 出版年：2016
- 出版时间：23 May 2016
- 年：2016
- 卷：26
- 期：10
- 页码：1312-1318
- 全文大小：2529 K
文摘
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Tropomyosins Tpm1.8/9 are enriched in the lamellipodium alongside Arp2/3
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Tpm1.8/9 knockdown enhances Arp2/3 activity
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Tpm1.8/9 promote lamellipodial persistence and cell motility
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Coronin 1B and cofilin cooperate to generate Tpm1.8/9-actin filaments