文摘
Coronin, GMF, and Arpin each induce related open conformations in Arp2/3 complex. GMF binding induces two distinct inhibitory states of Arp2/3 complex. Coronin, GMF, and Arpin combinatorially inhibit Arp2/3 complex activity. Arpin has two separate binding sites on Arp2/3 complex Arp2 and Arp3.