- 作者：Caroline Gomes ; Emerson Luiz Botelho Louren?o ; ¨¦rica Barbosa Liuti ; Aline Oliveira Duque ; Fabiola Nihi ; Ana Carolina Louren?o ; Tatiane Camacho Mendes ; Arquimedes Gasparotto Junior ; Paulo Roberto Dalsenter
- 关键词：Tropaeolum majus ; Subchronic toxicity ; Hematological analyses ; Biochemical analyses ; Histopathological analyses ; Wistar rats
- 刊名：Journal of Ethnopharmacology
- 出版年：2012
- 出版时间：13 July, 2012
- 年：2012
- 卷：142
- 期：2
- 页码：481-487
- 全文大小：846 K
Ethnopharmacological relevance
The use of medicinal plants for the treatment of diseases usually comes from the belief that they present low toxicity due their natural origin. However, it is necessary a toxicological and pharmacological evaluation for these plants. Tropaeolum majus is a medicinal plant used in popular medicine to treat several diseases, including cardiovascular disorders, urinary tract infections and asthma. Even though several studies proved its therapeutic effects, there are few toxicological studies with this species.Aim of the study
The present study was carried out to evaluate the subchronic toxicity of the hydroethanolic extract obtained from leaves of T. majus (HETM) in Wistar rats.
Material and methods
Male and female Wistar rats received three doses of HETM (75, 375 and 750 mg/kg) for 28 days. After the treatments biochemical, hematological and histopathological parameters were analyzed.
Results
No significant alterations in the animal's body weight gain, relative organs weight, serum biochemical analysis, hematological or histopathological analyses of liver, kidneys and spleen were observed.
Conclusions
These results demonstrate the absence of subchronic toxicity due to oral treatment with HETM for 28 days in Wistar rats. However, other toxicological studies are necessary to evaluate the total safety of this plant.