β-arrestin1 promotes epithelial-mesenchymal transition via modulating GSK-3β/β-catenin pathway in prostate cancer cells
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- 作者：Xiaolu Duana ; 1 ; Tao Zhanga ; 1 ; Zhenzhen Konga ; 1 ; Xin Maia ; Chuangxin Lana ; Dong Chena ; Yang Liua ; Zhiwen Zengb ; Chao Caia ; Tuo Denga ; Wenqi Wua ; Guohua Zenga ; gzgyzgh@vip.tom.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：β-arrestin1 ; Epithelial-mesenchymal transition ; GSK-3β/β-catenin pathway ; Prostate cancer
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：14 October 2016
- 年：2016
- 卷：479
- 期：2
- 页码：204-210
- 全文大小：2080 K
文摘
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β-arrestin1 initiates EMT and promotes the migration and invasion of prostate cancer cells.
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β-arrestin1 could increase the activity and expression of β-catenin.
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β-arrestin1 inhibits GSK-3β activity through modulating the activities of Akt and PP2A.
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β-arrestin1 functions as a key scaffold protein in modulating GSK-3β/β-catenin signaling.
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Duan and Guohua Zeng designed research; Duan, Zhang, Kong, Mai, Lan and Chen performed research; Cai, Deng and Zhiwen Zeng analyzed data; Duan and Wu wrote the paper.