Allosteric modulation of A₁-adenosine receptor: a review

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• 作者：Marí ; a Kimatrai-Salvador ; Pier Giovanni Baraldi ; ^pgb@unife.it ; Romeo Romagnoli
• 刊名：Drug Discovery Today: Technologies
• 出版年：2013
• 出版时间：Summer, 2013
• 年：2013
• 卷：10
• 期：2
• 页码：e285-e296
• 全文大小：408 K

文摘

Allosteric modulators of adenosine receptors represent an alternative to direct-acting adenosine agonists and nucleoside uptake blockers, preferably those can selectively modulate the response to adenosine in only those organs or localized areas of a given organ in which production of adenosine is increased. Allosteric enhancers at the adenosine A₁ receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, this class of compounds has therapeutic potential as analgesics and neuroprotective agents.