Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon

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• 作者：Kazuo Shimizu ; Swadesh K. Das ; Masaki Baba ; Yukinaga Matsuura and Kazuki Kanazawa
• 关键词：Cancer prevention ; Propolis ; Artepillin C ; Colon cancer ; Aberrant crypt foci ; Antioxidant-responsive element
• 刊名：Cancer Letters
• 出版年：2006
• 出版时间：18 August 2006
• 年：2006
• 卷：240
• 期：1
• 页码：135-142
• 全文大小：223 K

文摘

Artepillin C, a prenylated phenylpropanoid found specifically in Brazilian propolis, has been shown to be a bioavailable antioxidant. In this study, artepillin C was tested for colon cancer-preventing activity using azoxymethane-challenged ddY mice. Oral doses of 80 and 160 mg/kg body weight of propolis or 10 mg/kg of artepillin C (equi-amounts to 160 mg propolis) reduced significantly the frequency of colonic aberrant crypt foci (ACF) by 39.2, 43.7 and 43.4 % , respectively. In liver of the mice, glutathione S-transferase and NADPH:quinone reductase activity increased with the doses of propolis or artepillin C, and an antioxidant-responsive element (ARE) was found to be activated for binding DNA. Artepillin C is considered to suppress the formation of colonic ACF through the activation of ARE and induction of phase II enzymes in liver.