Effects of statin therapy on arterial stiffness: A systematic review and meta-analysis of randomized controlled trial

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• 作者：Sikarin Upala^a ; ^b ; ^{sikarin.upala@bassett.org} ; Kamonkiat Wirunsawanya^c ; ^{kamonac120@gmail.com} ; Veeravich Jaruvongvanich^c ; ^d ; ^{veeravich_j@hotmail.com} ; Anawin Sanguankeo^a ; ^b ; ^{anawin.sanguankeo@bassett.org}
• 关键词：Arterial stiffness ; Lipid lowering therapy ; Meta-analysis ; Pulse wave velocity ; Statin
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：338-341
• 全文大小：352 K
• 卷排序：227

文摘

Arterial stiffness has been observed to be an independent predictor for cardiovascular events. Effects of cholesterol lowering agents (statins) on arterial stiffness are inconsistent. We conducted a systematic review with a meta-analysis of all RCTs investigating the impact of statin therapy on arterial properties.MethodsWe comprehensively searched the databases of MEDLINE, EMBASE, and Cochrane from their dates of inception through April 2016. The inclusion criteria were published RCTs comparing change in arterial stiffness between statin administration and active control or placebo groups. Arterial stiffness is determined by aortic pulse wave velocity (PWV). We used a random-effects model and calculated pooled standardized mean difference (SMD) with 95% confidence intervals (CI) comparing change in PWV between the statin and control groups.ResultsSix studies were included in the meta-analysis. Statin therapy includes simvastatin, rosuvastatin, lovastatin, fluvastatin, and atorvastatin. Compared with the active control or placebo group, the statin therapy group had lower aPWV (SMD = 2.31, 95% CI: 1.15–3.45, Pheterogeneity = 0.07, I2 = 93%).ConclusionOur meta-analysis demonstrates that statin therapy has a beneficial effect on aortic arterial stiffness. Further studies should be conducted to assess the effects of this therapy on arterial stiffness at various sites and conditions.