Iron overload in the liver diagnostic and quantification
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- 作者：Jose M. Alú ; stiza ; Agustin Castiella ; Maria D. De Juan ; Jose I. Emparanza ; Jose Artetxe ; Maite Uranga
- 关键词：Hemochromatosis 761.659 ; Liver biopsy 761.1261 ; Liver diseases 761.659 ; Magnetic resonance (MR) comparative studies 761.121411 ; 761.121412
- 刊名：European Journal of Radiology
- 出版年：2007
- 出版时间：March 2007
- 年：2007
- 卷：61
- 期：3
- 页码：499-506
- 全文大小：737 K
文摘
Hereditary Hemochromatosis is the most frequent modality of iron overload. Since 1996 genetic tests have facilitated significantly the non-invasive diagnosis of the disease.
There are however many cases of negative genetic tests that require confirmation by hepatic iron quantification which is traditionally performed by hepatic biopsy.
There are many studies that have demonstrated the possibility of performing hepatic iron quantification with Magnetic Resonance. However, a consensus has not been reached yet regarding the technique or the possibility to reproduce the same method of calculus in different machines.
This article reviews the state of the art of the question and delineates possible future lines to standardise this non-invasive method of hepatic iron quantification.