Characterization of a novel acquired der(1)del(1)(p13p31)t(1;15)(q42;q15) in a high risk t(12;21)-positive acute lymphoblastic leukemia
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- 作者：Eigil Kjeldsen eigil.kjeldsen@clin.au.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：BAC ; bacterial artificial chromosome ; BCP-ALL ; B-cell precursor acute lymphoblastic leukemia ; FISH ; fluorescence in situ hybridization ; MRD ; minimal residual disease ; oaCGH ; oligo-based array comparative genomic hybridization
- 刊名：Gene
- 出版年：2016
- 出版时间：20 December 2016
- 年：2016
- 卷：595
- 期：1
- 页码：39-48
- 全文大小：889 K
文摘
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An adolescent high risk t(12;21)+ ALL with a slow early treatment response was investigated
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A novel complex chromosomal rearrangement involving chromosomes 1 and 15 was characterized
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Novel aberrations were der(1)del(1)(p13p13)del(1)(q31q31)del(1)(q42q43)t(1;15)(q42;q15) and der(15)del(15)(q15q15)t(1;15)
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The presented findings add to the full spectrum of secondary chromosomal aberrations in t(12;21)+ ALL
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Molecular cytogenetics and aCGH analysis needs to be applied in routine cytogenetics diagnostics for adequate patient care