Copper-mediated N- and O-arylations with arylboronic acids in a continuous flow microreactor: a new avenue for efficient scalability
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- 作者：Brajendra K. Singh ; Christian V. Stevens ; Davy R.J. Acke ; Virinder S. Parmar ; Erik V. Van der Eycken
- 关键词：Copper-mediated ; N-Arylation ; O-Arylation ; Arylboronic acid ; Continuous flow ; Microreactor ; Scalability
- 刊名：Tetrahedron Letters
- 出版年：2009
- 出版时间：7 January 2009
- 年：2009
- 卷：50
- 期：1
- 页码：15-18
- 全文大小：194 K
文摘
A continuous flow procedure has been elaborated for the copper(II)-mediated N- and O-arylation of a range of compounds with arylboronic acids using a commercial microreactor setup. The compounds could be continuously generated in good yields paving the way for efficient scalability.