Regioselective arylation of uracil and 4-pyridone derivatives via copper(I) bromide mediated C-H bond activation

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• 作者：Chien Cheng^a ; Yu-Chiao Shih^a ; Hui-Ting Chen^b ; ; Tun-Cheng Chien^a ; ^{tcchien@ntnu.edu.tw}
• 关键词：C&ndash ; H activation ; Uracil ; 4-Pyridone ; Arylation ; Catalysis
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：28 January, 2013
• 年：2013
• 卷：69
• 期：4
• 页码：1387-1396
• 全文大小：563 K

文摘

A facile and effective synthesis of 6-aryluracil derivatives was accomplished by the direct C-H bond activation for arylation. A series of 6-aryl-1,3-dimethyluracils were synthesized from the reaction of 1,3-dimethyluracil with various phenyl iodides in DMF, in the presence of copper(I) bromide as the catalyst and lithium tert-butoxide as the base. This methodology is applicable to a variety of 5-substituted uracils as well as 4-pyridone to provide direct accesses to versatile uracil and 4-pyridone derivatives.