Stereoselective synthesis of (−)-3-PPP through palladium-catalysed unactivated C(sp³)-H arylation at the C-3 position of l-pipecolinic acid

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• 作者：Shi-Jin Zhang^a ; Wen-Wu Sun^b ; Qun-Ying Yu^c ; Pei Cao^c ; Xiao-Ping Dong^a ; Bin Wu^b ; ^c ; ^{wubin@mail.kib.ac.cn}
• 关键词：Preclamol ; Stereoselective ; Palladium ; C(sp3)-H activation ; Arylation
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：58
• 期：7
• 页码：606-609
• 全文大小：560 K
• 卷排序：58

文摘

An efficient route for the preparation of (−)-3-PPP is described. The chiral center formed in the key reaction was completely induced by the adjacent stereocenter of the substrate. Substitution effect of nitrogen on the efficiency of the key reaction was explored with substantial experiments.