A one-pot approach to 10-(1H-1,2,3-triazol-1-yl)pyrimido[1,2-a]indoles via aryne-mediated transformations of 3-(pyrimidin-2-yl)-1,2,4-triazines
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- 作者：Dmitry S. Kopchuka ; b ; Nikolay V. Chepchugova ; Albert F. Khasanova ; Igor S. Kovaleva ; Sougata Santraa ; Emiliya V. Nosovaa ; b ; Grigory V. Zyryanova ; b ; gvzyryanov@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Adinath Majeec ; Vladimir L. Rusinova ; b ; Oleg N. Chupakhina ; b
- 关键词：1 ; 2 ; 4-Triazines ; 1 ; 2-Dehydrobenzene ; 4 ; 5-Difluoro-1 ; 2-dehydrobenzene ; Transformations ; 10-(1H-1 ; 2 ; 3-Triazol-1-yl)pyrimido[1 ; 2-a]indoles
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：24 August 2016
- 年：2016
- 卷：57
- 期：34
- 页码：3862-3865
- 全文大小：619 K
文摘
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An efficient synthetic approach to 10-(1H-1,2,3-triazol-1-yl)pyrimido[1,2-a]indoles was developed.
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Only readily available reagents, simple procedures, and short reaction times were used.
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Difluoro-benzyne results in the corresponding 2,3-difluoro-pyrimido[1,2-a]indoles.
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This procedure will open up new routes for the synthesis of pyrimido[1,2-a]indoles.