Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults
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- 作者：Brandilyn A. Petersa ; 1 ; Megan N. Hallb ; Xinhua Liuc ; Vesna Slavkovicha ; Vesna Ilievskia ; Shafiul Alamd ; Abu B. Siddiqued ; Tariqul Islamd ; Joseph H. Grazianoa ; Mary V. Gamblea ; mvg7@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：As ; arsenic ; AS3MT ; arsenic methyltransferase ; bAs ; blood arsenic ; CKD ; chronic kidney disease ; DMA ; dimethylarsinic acid ; eGFR ; estimated glomerular filtration rate ; GFR ; glomerular filtration rate ; InAs ; inorganic arsenic ; MMA ; monomethylarsonic acid ; SG ; specific gravity ; uAs ; urinary arsenic
- 刊名：Environmental Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：143
- 期：part_PA
- 页码：123-130
- 全文大小：433 K
文摘
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We examined the association between renal function and As methylation capacity.
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Blood and urine As metabolites and eGFR were analyzed in 375 As-exposed adults.
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eGFR was significantly associated with increased %InAs and decreased %DMA in urine.
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The relationship between %InAs in blood vs. in urine was weaker in low eGFR strata.
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Urinary excretion of InAs may be impaired in those with reduced eGFR.