Hydrogen peroxide triggers a novel alternative splicing of arsenic (+3 oxidation state) methyltransferase gene
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- 作者：Daigo Sumi ; Chieri Takeda ; Daiki Yasuoka ; Seiichiro Himeno ; himenos@ph.bunri-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arsenic (+3 oxidation state) methyltransferase ; Methyltransferase activity ; Alternative splicing
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：4 November 2016
- 年：2016
- 卷：480
- 期：1
- 页码：18-22
- 全文大小：504 K
文摘
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AS3MT detoxifies arsenic by catalyzing the methylation of inorganic arsenic.
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Abnormal splice form (Δ3-10) of AS3MT mRNA was induced by H2O2.
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H2O2 reduced the level of SRp40 that positively controls AS3MT mRNA splicing.
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Arsenic methylation activity was decreased in cells exposed to H2O2.
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H2O2 may suppress arsenic methylation via disturbing normal splicing of AS3MT.