The amphiphilic alkyl ester derivatives of l-ascorbic acid induce reorganization of phospholipid vesicles
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- 作者：Francesca Giudice ; Ernesto E. Ambroggio ; ernesto@fcq.unc.edu.ar" class="auth_mail" title="E-mail the corresponding author ; Milagro Mottola1 ; Maria Laura Fanani ; lfanani@fcq.unc.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：GUVs ; LUVs ; Laurdan GP ; DPH anisotropy ; Phosphatidylcholine liposomes ; Confocal microscopy
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1858
- 期：9
- 页码：2132-2139
- 全文大小：979 K
文摘
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l-ascorbic acid alkyl esters (ASCn) develop different effects on POPC vesicles.
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ASC12 partitions scarcely and superficially into the bilayer affecting its properties.
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ASC14 strongly modulates the membrane tension, permeability, and rheology.
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ASC16 forms drug-enriched condensed domains in the lipid membrane.
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ASCn accumulation into the biomembrane enhances its local capacity as antioxidant.