More than the genes, the tumor microenvironment in neuroblastoma
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- 作者：Lucia Borrielloa ; b ; c ; Robert C. Seegera ; b ; c ; Shahab Asgharzadeha ; b ; c ; Yves A. DeClercka ; b ; c ; d ; declerck@usc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：TME ; Tumor microenvironment ; TAM ; Tumor-associated macrophages ; TAF ; Tumor-associated fibroblasts ; MSC ; Mesenchymal stromal cells ; BM ; Bone marrow ; ECM ; Extracellular matrix
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 September 2016
- 年：2016
- 卷：380
- 期：1
- 页码：304-314
- 全文大小：1754 K
文摘
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There is now evidence that the extracellualr matrix and normal cells in the tumor microenvironment of neuroblstoma tumors and metastases contribute to progression.
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The communication between neuroblstoma cells and stromal cells is through a combination of adhesion-dependent and adhesion-independent mechnnisms.
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New therapies targeting these mechanims are now tested in multiple early phase clinical trials.