Solvent-free lipase-catalyzed synthesis of a novel hydroxyl-fatty acid derivative of kojic acid

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• 作者：Noureddin El-Boulifi ; Siti Efliza Ashari ; Marta Serrano ; Jose Aracil ; Mercedes Mart铆nez
• 关键词：Esterification ; Hydroxyl-fatty acid ; Kojic acid ; Lipase ; Optimization ; Solvent-free system
• 刊名：Enzyme and Microbial Technology
• 出版年：5 February, 2014
• 年：2014
• 卷：55
• 期：Complete
• 页码：128-132
• 全文大小：558 K

文摘

The aim of this work was the synthesis of a novel hydroxyl-fatty acid derivative of kojic acid rich in kojic acid monoricinoleate (KMR) which can be widely used in the cosmetic and food industry. The synthesis of KMR was carried out by lipase-catalysed esterification of ricinoleic and kojic acids in solvent-free system. Three immobilized lipases were tested and the best KMR yields were attained with Lipozyme TL IM and Novozym 435. Since Lipozyme TL IM is the cheapest, it was selected to optimize the reaction conditions. The optimal reaction conditions were 80 掳C for the temperature, 1:1 for the alcohol/acid molar ratio, 600 rpm for stirring speed and 7.8% for the catalyst concentration. Under these conditions, the reaction was scaled up in a 5 脳 10^鈭? m³ stirred tank reactor. ¹H-¹³C HMBC-NMR showed that the primary hydroxyl group of kojic acid was regioselectively esterified. The KMR has more lipophilicity than kojic acid and showed antioxidant activity that improves the oxidation stability of biodiesel.