Osteoclasts are involved in the maintenance of dormant leukemic cells

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• 作者：Asumi Yokota ; Shinya Kimura ; Ruriko Tanaka ; Miki Takeuchi ; Hisayuki Yao ; Kazuki Sakai ; Rina Nagao ; Junya Kuroda ; Yuri Kamitsuji ; Eri Kawata ; Eishi Ashihara ; Taira Maekawa
• 关键词：Osteoclasts ; Osteoblasts ; TGF-β ; ₁ ; Bone marrow microenvironment
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：34
• 期：6
• 页码：793-799
• 全文大小：922 K

文摘

Osteoclasts (OCs) are specialized cells for the resorption of bone matrix that have also been recently reported to be involved in the mobilization of hematopoietic progenitor cells. When Ba/F3 cells expressing wild-type bcr-abl were co-cultured with osteoblasts (OBs), OCs, and bone slices, their proliferation was significantly suppressed, and the Ki-67 negative population, which is believed to be in G₀ phase, was increased. The results of our in vitro experiments suggest that OCs could be involved in the maintenance of dormant leukemic cells in the bone marrow (BM) microenvironment through the release of soluble factors, one of which could be TGF-β.