CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species
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- 作者：Hisashi Takeuchi ; M.D. ; Ph.D.a ; 1 ; Rikiya Taoka ; M.D. ; Ph.D.a ; 1 ; Chinedu O. Mmeje ; M.D.a ; Goodwin G. Jinesh ; Ph.D.a ; Stephen Safe ; Ph.D.b ; Ashish M. Kamat ; M.D.a ; akamat@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bladder cancer ; Specificity protein (Sp) transcription factors ; Reactive oxygen species (ROS) ; Antioxidants ; Targeted therapy ; Anticancer agents
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：34
- 期：8
- 页码：337.e11-337.e18
- 全文大小：1871 K
文摘
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CDODA-Me shows antineoplastic activity in bladder cancer cells by inducing ROS.
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CDODA-Me down-regulates Sp and Sp-regulated proteins through ROS induction.
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VEGFR2 is an important SP-1 target that was down-regulated by CDODA-Me.
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CDODA-Me inhibits proliferation and induces apoptosis in tumor cells in vivo.