Gene delivery to neuroblastoma cells by poly (l-lysine)-grafted low molecular weight polyethylenimine copolymers
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- 作者：Saeedeh Askariana ; c ; Askarians891@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Khalil Abnousb ; Abnouskh@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Majid Darroudic ; DarroudiM@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Reza Kazemi Oskueea ; d ; Oskueekr@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Mohammad Ramezanib ; Ramezanim@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytotoxicity ; Gene delivery ; Nanoparticles ; Non-viral vector ; Poly (l-lysine) ; Polyethylenimine
- 刊名：Biologicals
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：44
- 期：4
- 页码：212-218
- 全文大小：979 K
文摘
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Different molecular weight PEIs (1.8 kDa and 10 kDa) conjugated to Poly (L-lysine) via 6-cabone alkyl linker.
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Four nanoparticles were synthesized with different combination of PEI polycations.
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Modified polymers showed better transfection efficiency and less cytotoxicity in compare to unmodified PEI and PLL.
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PLP10-10% was the best gene transfer carrier as compared to unmodified PEIs.