MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs
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- 作者：Mé ; lanie A. Eckersley-Maslin1 ; eckersleym@babraham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Valentine Svensson2 ; 3 ; Christel Krueger1 ; Thomas M. Stubbs1 ; Pascal Giehr4 ; Felix Krueger5 ; Ricardo J. Miragaia2 ; 3 ; 6 ; Charalampos Kyriakopoulos7 ; Rebecca V. Berrens1 ; Inê ; s Milagre1 ; Jö ; rn Walter4 ; Sarah A. Teichmann2 ; 3 ; Wolf Reik1 ; 3 ; 8 ; wolf.reik@babraham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zscan4 ; MERVL ; endogenous retrovirus ; embryonic stem cell ; DNA methylation ; imprint ; preimplantation ; reprogramming ; chromatin
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：179-192
- 全文大小：4484 K
文摘
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Single-cell transcriptomics reveals dynamics of MERVL/Zscan4 network activation
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MERVL-LTR transcriptional network is expressed in iPSC reprogramming events
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Translation block depletes Dnmt proteins, inducing transient global demethylation
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Passage through the MERVL/Zscan4 state may cause irreversible imprint erasure