Primary central nervous system histiocytic sarcoma presenting as a postradiation sarcoma: case report and literature review

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• 作者：Winnie Wu ; MD^a ; ^{winniewu@mednet.ucla.edu} ; Asli Tanrivermis Sayit ; MD^b ; Harry V. Vinters ; MD^a ; ^c ; Whitney Pope ; MD ; PhD^b ; Leili Mirsadraei ; MD^a ; Jonathan Said ; MD^a
• 关键词：CNS histiocytic sarcoma ; Postradiation sarcoma
• 刊名：Human Pathology
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：44
• 期：6
• 页码：1177-1183
• 全文大小：5027 K

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Summary

Histiocytic sarcoma (HS) is a rare neoplasm that occurs most commonly in the intestinal tract, skin, soft tissue, and lymph node. The incidence of primary central nervous system (CNS) HS is even rarer, with a total of 6 cases reported in the literature. An etiologic link has not been identified for CNS HS, and the current case of primary CNS HS is unique in that an etiologic link to prior radiation therapy is identified, associated with complex cytogenetic abnormalities in the tumor. Although radiation-associated sarcomas can present as any number of different pathologic entities, this is the first reported case of a radiation-associated CNS HS. The pathologic and immunophenotypic characteristics of this case, with a nearly obscuring heavy inflammatory infiltrate and expression of monocytic/histiocytic markers (CD163, CD68, CD4, fascin), are characteristic of CNS HS. A discussion of the differential diagnosis and review of relevant literature are presented.