Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection

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• 作者：Boatto ; Gianpiero ; Nieddu ; Maria ; Carta ; Antonio ; Pau ; Amedeo ; Palomba ; Michele ; Asproni ; Battistina ; et. al.
• 关键词：Methylenedioxy-derivates ; Amphetamine ; Phenylethylamine ; Designer drug ; Urine ; Capillary electrophoresis ; Mass spectrometry ; Solid-phase extraction (SPE)
• 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
• 出版年：2005
• 出版时间：January 5, 2005
• 年：2005
• 卷：814
• 期：1
• 页码：93-98
• 全文大小：191 K

文摘

In recent years, a number of newer designer drugs have entered the illicit drug market. The methylenedioxy-derivates of amphetamine represent the largest group of designer drugs. This paper describes a method for screening for and quantification of ten 2,5-methylenedioxy-derivates of amphetamine and phenylethylamine in human urine, using capillary electrophoresis coupled to electrospray ionisation–mass spectrometry (CE–ESI–MS). Prior to CE–MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validates according to international guidelines.