Synthesis of N-[4-(alkyl)cyclohexyl]-substituted benzamides with anti-inflammatory and analgesic activities

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• 作者：Pau ; Amedeo ; Boatto ; Gianpiero ; Palomba ; Michele ; Asproni ; Battistina ; Cerri ; Riccardo ; Palagiano ; Francesco ; et. al.
• 关键词：N-[4-(Alkyl)cyclohexyl]-substituted benzamides ; Anti-inflammatory agents ; Analgesic agents
• 刊名：Il Farmaco
• 出版年：1999
• 出版时间：August 30, 1999
• 年：1999
• 卷：54
• 期：8
• 页码：524-532
• 全文大小：132 K

文摘

Two series of N-[4-(alkyl)cyclohexyl]-substituted benzamides, i.e. a series of N-[4-(tert-butyl)cyclohexyl]-substituted benzamides and a series of N-[4-(ethyl)cyclohexyl]-substituted benzamides, were synthesised and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability.